منابع مشابه
Math 762 Differential Topology
This course will explain the fundamental concepts of topology for smooth manifolds. After developing the fundamental tool of transversality theory (we prove Sard’s theorem) we will prove the Brouwer Fixed Point Theorem, the Brouwer No Retraction Theorem, and the Whitney Embedding Theorem, and the “27 lines on a cubic surface” using this tool. Then we cover Morse Theory and use it to classify 2-...
متن کامل2010 UCSD - AMGEN Scholars Program
The main targets of HIV infection are CD4 T cells, and consequently their cell numbers decline with increasing viral load, causing weakened immunity. Previous studies have demonstrated that the level of activated CD8 T cells co-expressing CD38 in the peripheral blood is highly correlated with HIV load and is predictive of progression of infection to AIDS. Although activation of infected CD4 T c...
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Neural connectivity between the spinal cord and paired appendages is key to the superior locomotion of tetrapods and aquatic vertebrates. In contrast to nerves that innervate axial muscles, those innervating appendages converge at a specialized structure, the plexus, where they topographically reorganize before navigating towards their muscle targets. Despite its importance for providing append...
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Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), but recent data indicate that they may also be substrates of these multidrug transporters (MDTs). The present study was designed to investigate potential transport of ELC and TQD by MDTs at the blood-brain barrier at tracer doses as used...
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The pharmacokinetics (PK) of biologic therapeutics, especially monoclonal antibodies (mAbs), in monkeys generally presents the most relevant predictive PK information for humans. However, human mAbs, xenogeneic proteins to monkeys, are likely to be immunogenic. Monkeys previously treated with a human mAb (nonnaïve) may have developed antidrug antibodies (ADAs) that crossreact with another test ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2013
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0313-182